A and B are single compounds containing two identical building blocks where as A-B and B-A represents positional isomers each containing two building blocks.
This analysis was conducted on the crude liquid-phase reaction mixture. Each component contains multiple secondary and tertiary amine functionality yet the combinatorial products can be rapidly chromatographed and exhibit no tailing on a HAISIL HL C18 column using a simple linear 5 to 100% MeCN/water 0.1%TFA gradient.
Column: HAISIL C18 (High Load) 4.6x150mm P/N: H LS-1546-C185
Higgins Analytical is grateful to Krishna Kalghatgi of NeoGenesis for sharing these data.
© 1998 Higgins Analytical, Inc. (23Sept98)