RPC of Basic Compounds
in Combinatorial Mixtures
A and B are single
compounds containing two identical building blocks where as A-B and B-A
represents positional isomers each containing two building blocks.
was conducted on the crude liquid-phase reaction mixture. Each component
contains multiple secondary and tertiary amine functionality yet the combinatorial
products can be rapidly chromatographed and exhibit no tailing on a HAISIL
HL C18 column using a simple
linear 5 to 100% MeCN/water 0.1%TFA gradient.
C18 (High Load) 4.6x150mm P/N:
is grateful to Krishna Kalghatgi of NeoGenesis for sharing these
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