Antibody Concentration & Desalting Columns
We have developed a gentle method for the desalting and concentration of biologics in a single easy step. The benefits of our method compared with current membrane-based spin columns:
No additional stress added to the proteins
Single and rapid step: 4 min process vs. up to 20min process
Up to 100% recovery
Compatible with most downstream analyses
Concentration and Desalting of a Human Serum IgG Solution
CE-SDS Analysis of Before and After Use of a ConSep Column
HisSep, is a spin column product optimized for the rapid and gentle removal of histidine from formulation buffers. Histidine is an excipient which is being used in biologics formulations of monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs). Histidine itself, however, interferes with formulation analyses by amino acid analysis and isoelectric focusing. As many of these analyses are used in conjunction with stability studies, the use of membrane filtration devices for histidine removal can add an additional unquantifiable "stress" component to the result of these analyses.
- HisSep Application sheet
Expanded Capacity, HisSep-250™ Protocol
Prices Histidine Removal Kits
Increased Accuracy of Antibody Assays After Histidine Removal
Go back to menu.
The Nest Group, Inc.™ 45 Valley Road Southborough, MA 01772-1323 USA
Tel: 800-347-6378 or 1-508-481-6223 Fax: 1-508-485-5736
For your convenience, we accept Mastercard, VISA, and American Express credit cards.
| Home | IdeaBook | Ordering | Price/Applic | Price/Vendor | Protocols|